A new synthetic route towards the mono-O-protected anti-conformationally constrained pyrimidine acyclic nucleoside.
نویسندگان
چکیده
Novel synthetic approach to mono-O-protected anti-conformationally constrained pyrimidine acyclic nucleoside was attained from the coupling of lithiated 2,4-dimethoxy-6-methylpyrimidine with 1-benzyloxy-3-(tert-butyldiphenylsilyloxy)propan-2-one, followed by the sequential reactions of methylthiomethylation, cyclization, hydroxylation, and dealkylation.
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ورودعنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 50 8 شماره
صفحات -
تاریخ انتشار 2002